Basic information of CNR1 :
| Official Symbol of Gene | CNR1 |
| Species | Homo sapiens |
| Entrez Gene ID | 1268 |
| Official Full Name | cannabinoid receptor 1 |
| Also known as | CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000118432 MIM:114610; AllianceGenome:HGNC:2159 |
| Map Location | 6q15 |
| Variation Type | allele |
| refSNP ID | short AAT , long AAT |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Italians |
| Sample Size | 114 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 24391723 |
| Year | 2013 |
| Title | Association between a genetic variant of type-1 cannabinoid receptor and inflammatory neurodegeneration in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Negative |
| Result | The two genotype groups (short and long AAT) did not differ in terms of the main clinical and demographic characteristics. |
| Mechanism/Pathway | Genetic ablation of CB1Rs exacerbates the neurodegenerative damage associated with experimental autoimmune encephalomyelitis (EAE), a reliable mouse model of multiple sclerosis (MS), by altering synaptic sensitivity to pro-inflammatory cytokines released by infiltrating immune cells and by activated microglia. Inflammation leads to neuronal damage also in the human brain, and indeed higher frequency and severity of inflammatory episodes have been associated with accelerated neurodegeneration and disability accumulation in MS. |
