Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | allele |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral granulocytes |
| Sample Detail | N/A |
| Detected Method | PCR-SSOP |
| Disease | MS |
| Disease subtype | RRMS,RPMS |
| Population | Japanese |
| Sample Size | 89 Western type MS patients / 57 Asian type MS patients / 146 healthy |
Literature information of multiple sclerosis :
| Pubmed ID | 9894852 |
| Year | 1998 |
| Title | Molecular analysis of HLA class I (HLA-A and -B) and HLA class II (HLA-DRB1) genes in Japanese patients with multiple sclerosis (Western type and Asian type) |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Positive association between total MS patients and controls was observed in HLA-DRB1*1501.The frequency of DRB1*0901 was decreased in total MS as well as in both Western and Asian type MS. The frequency of HLA DRB1*1501 was increased in Western type MS compared with controls.The frequency of DRB1*1501 did not differ significantly between patients with Asian type MS and controls. The frequency of DRB1*0802 was however increased in Asian type MS when compared with controls. |
| Mechanism/Pathway | N/A |
