Basic information of NCF1 :
| Official Symbol of Gene | NCF1 |
| Species | Homo sapiens |
| Entrez Gene ID | 653361 |
| Official Full Name | neutrophil cytosolic factor 1 |
| Also known as | CGD1; NCF1A; NOXO2; p47phox; SH3PXD1A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000158517 MIM:608512; AllianceGenome:HGNC:7660 |
| Map Location | 7q11.23 |
| Variation Type | Deletion |
| refSNP ID | dinucleotide deletion (ΔGT) in exon 2 |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Polish |
| Sample Size | 187 MS patients / 184 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 19077231 |
| Year | 2008 |
| Title | NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | DeltaGT/GTGT ratios were not associated with susceptibility to MS. |
| Mechanism/Pathway | The ΔGT/GTGT ratio influences the expression levels of NCF1 most probably by the occurrence of an NCF1 transcript from the type II pseudogene that does not contain the GT deletion, which leads to a premature stop codon in the type I pseudogene. |
