Basic information of IL21 :
| Official Symbol of Gene | IL21 |
| Species | Homo sapiens |
| Entrez Gene ID | 59067 |
| Official Full Name | interleukin 21 |
| Also known as | Za11; IL-21; CVID11 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000138684 MIM:605384; AllianceGenome:HGNC:6005 |
| Map Location | 4q27 |
| Variation Type | SNP |
| refSNP ID | rs2055979 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iraqi |
| Sample Size | 70 MS / 50 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 35891764 |
| Year | 2022 |
| Title | Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The results of the study revealed a significant reduction in the distribution of the wild homozygous genotype (GG) in MS patients, in comparison to a healthy control group.However, MS cases and controls did not differ significantly in neither GT nor TT genotypes, |
| Mechanism/Pathway | B-cell proliferation is induced by IL-21, which improves their function by increasing antibody production and reducing cell death. It is also been linked to controlling antibody development and preventing apoptosis and plasma cell differentiation. The cluster of differentiation 81 T cells, NK cells, and NK T cells are activated by IL-21, which enhances their cytotoxic activity and proliferation. |
