Basic information of Ptpn6 :
| Official Symbol of Gene | Ptpn6 |
| Species | Mus musculus |
| Entrez Gene ID | 15170 |
| Official Full Name | protein tyrosine phosphatase, non-receptor type 6 |
| Also known as | me; hcp; Hcph; Ptp1C; SHP-1; 70Z-SHP; SH-PTP1; PTPTY-42 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000004266 AllianceGenome:MGI:96055 |
| Map Location | 6 F2; 6 59.17 cM |
| Variation Type | Deletion |
| refSNP ID | me+/- |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | EAE |
| Disease subtype | N/A |
| Population | B10.PL mice, C57BL/6 mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 11970996 |
| Year | 2002 |
| Title | Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | mev-/- mice had a higher incidence of disease and developed a more severe course of EAE. |
| Mechanism/Pathway | SHP-1 is a cytosolic tyrosine phosphatase that is involved in regulating the T cell activation cascade from signals initiated through the TCR.SHP-1-deficient mice have severe defects in immunity and hemopoiesis. |
