Basic information of MMP9 :
| Official Symbol of Gene | MMP9 |
| Species | Homo sapiens |
| Entrez Gene ID | 4318 |
| Official Full Name | matrix metallopeptidase 9 |
| Also known as | GELB; CLG4B; MMP-9; MANDP2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000100985 MIM:120361; AllianceGenome:HGNC:7176 |
| Map Location | 20q13.12 |
| Variation Type | polymorphism |
| refSNP ID |
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Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,SPMS |
| Population | Serbian |
| Sample Size | 187 MS /282 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 17655938 |
| Year | 2007 |
| Title | Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | In the patients group overall, genotype and allele frequency distributions were not significantly different between patients and controls. We found a significant decrease in T allele carrier frequency in female patients with MS compared to healthy female controls. |
| Mechanism/Pathway | Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in remodeling of the extracellular matrix. They are suggested to play a role in the influx of inflammatory cells into the CNS, disruption of the BBB, and have been shown to degrade myelin in vitro . |
