Basic information of LEP :
| Official Symbol of Gene | LEP |
| Species | Homo sapiens |
| Entrez Gene ID | 3952 |
| Official Full Name | leptin |
| Also known as | OB; OBS; LEPD |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000174697 MIM:164160; AllianceGenome:HGNC:6553 |
| Map Location | 7q32.1 |
| Variation Type | SNP |
| refSNP ID | rs7799039 or -2,548G > A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | N/A |
| Sample Size | 305 MS patients / 255 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 30219158 |
| Year | 2018 |
| Title | Gender-Specific Association of Leptin and Adiponectin Genes With Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | After classification of LEP rs7799039 genotypes to high (AA) and intermediate+low (AG+GG) leptin producers, it has been revealed that the frequency of high leptin producer genotype was significantly higher in male patients compared to male controls. |
| Mechanism/Pathway |
MS is mainly considered a Th1-mediated inflammatory disease,although recent studies postulate a vital role for helper T cells-17 (Th17 cells) in the pathogenesis of the disease .Therefore, the pathogenesis of MS is influenced by factors that affect the deviation of na |
