Basic information of LEP :
| Official Symbol of Gene | LEP |
| Species | Homo sapiens |
| Entrez Gene ID | 3952 |
| Official Full Name | leptin |
| Also known as | OB; OBS; LEPD |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000174697 MIM:164160; AllianceGenome:HGNC:6553 |
| Map Location | 7q32.1 |
| Variation Type | SNP |
| refSNP ID | rs7799039 or -2,548G > A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | N/A |
| Sample Size | 305 MS patients / 255 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 30219158 |
| Year | 2018 |
| Title | Gender-Specific Association of Leptin and Adiponectin Genes With Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Negative |
| Result | The results did not show any significant association between clinical parameters (including the EDSS score, progression index and the age of disease onset) and different studies genotypes of LEP gene polymorphisms. Also, there were no significant differences in the distributions of LEP rs7799039 genotypes in MS patients with different types of the disease . |
| Mechanism/Pathway |
MS is mainly considered a Th1-mediated inflammatory disease,although recent studies postulate a vital role for helper T cells-17 (Th17 cells) in the pathogenesis of the disease .Therefore, the pathogenesis of MS is influenced by factors that affect the deviation of na |
