Basic information of ADIPOQ :
| Official Symbol of Gene | ADIPOQ |
| Species | Homo sapiens |
| Entrez Gene ID | 9370 |
| Official Full Name | adiponectin, C1Q and collagen domain containing |
| Also known as | ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000181092 MIM:605441; AllianceGenome:HGNC:13633 |
| Map Location | 3q27.3 |
| Variation Type | SNP |
| refSNP ID | rs1501299 or +276G > T |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | N/A |
| Sample Size | 305 MS patients / 255 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 30219158 |
| Year | 2018 |
| Title | Gender-Specific Association of Leptin and Adiponectin Genes With Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | rs1501299 (+276G>T) polymorphism in the second exon of ADIPOQ gene also showed a significant association with MS susceptibility in male patients.In fact, the frequency of rs1501299 intermediate+low adiponectin producer genotypes (TG+GG) and low adiponectin producer allele (rs1501299G) were significantly higher in male patients compared to male controls. |
| Mechanism/Pathway |
MS is mainly considered a Th1-mediated inflammatory disease,although recent studies postulate a vital role for helper T cells-17 (Th17 cells) in the pathogenesis of the disease .Therefore, the pathogenesis of MS is influenced by factors that affect the deviation of na |
