Basic information of IL1B :
| Official Symbol of Gene | IL1B |
| Species | Homo sapiens |
| Entrez Gene ID | 3553 |
| Official Full Name | interleukin 1 beta |
| Also known as | IL-1; IL1F2; IL1beta; IL1-BETA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000125538 MIM:147720; AllianceGenome:HGNC:5992 |
| Map Location | 2q14.1 |
| Variation Type | polymorphism |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,SPMS |
| Population | Japanese |
| Sample Size | 98 MS patients / 104 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 11498264 |
| Year | 2001 |
| Title | Genetic polymorphisms of IL-1beta and IL-1 receptor antagonist in association with multiple sclerosis in Japanese patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | IL-1beta gene polymorphisms may not be relevant in the susceptibility to MS or the clinical characteristics of Japanese patients with MS. |
| Mechanism/Pathway | IL-1 is predominantly expressed by macrophages within the lesion centers and by microglia at and beyond the lesion edge. This expression of IL-1 may participate in the destruction of the central nervous system myelin. |
