Basic information of IL6 :
| Official Symbol of Gene | IL6 |
| Species | Homo sapiens |
| Entrez Gene ID | 3569 |
| Official Full Name | interleukin 6 |
| Also known as | CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000136244 MIM:147620; AllianceGenome:HGNC:6018 |
| Map Location | 7p15.3 |
| Variation Type | SNP |
| refSNP ID | rs1818879 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqMan Validate SNP Genotyping Assay |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Caucasian |
| Sample Size | 171 RR-MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 35627281 |
| Year | 2022 |
| Title | Interleukin 6 SNP rs1818879 Regulates Radiological and Inflammatory Activity in Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | We found a significant association between rs1818879 and PC1.A significant association emerged between the SNP rs1818879 and radiological activity at diagnosis. In particular, the presence of the A allele was associated with a higher prevalence of gadolinium-enhancing lesions at the time of diagnosis.In rs1818879, A minor allele carriers significantly increasing CSF levels of both pro-inflammatory and anti-inflammatory cytokines have been observed. |
| Mechanism/Pathway | Interleukin (IL)-6 represents one of the most important pro-inflammatory cytokines in the pathophysiology of MS. |
