Basic information of IFNG :
| Official Symbol of Gene | IFNG |
| Species | Homo sapiens |
| Entrez Gene ID | 3458 |
| Official Full Name | interferon gamma |
| Also known as | IFG; IFI; IMD69 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000111537 MIM:147570; AllianceGenome:HGNC:5438 |
| Map Location | 12q15 |
| Variation Type | SNP |
| refSNP ID | 874A/T |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | allele-specific PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Azerbaijani |
| Sample Size | 152 Azeri MS patients / 240 healthy |
Literature information of multiple sclerosis :
| Pubmed ID | 32368988 |
| Year | 2021 |
| Title | IFN-γ and TNF-α Gene Polymorphisms in Multiple Sclerosis Patients in Northwest Iran |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | In the IFN-γ +874A/T gene single nucleotide polymorphism (SNP), the most allelic and genotypic frequencies in MS patients were the A allele and the AT genotype.The T allele in the IFN-γ gene (+874) was considered as potential risk factors for MS. |
| Mechanism/Pathway | Cytokines are polypeptides that play critical roles in immune responses. Gene polymorphisms occurring in the inflammatory cytokines are taking a role in autoimmune diseases, including multiple sclerosis (MS), which may induce inappropriate immune responses. |
