Basic information of TNF :

Official Symbol of Gene	TNF
Species	Homo sapiens
Entrez Gene ID	7124
Official Full Name	tumor necrosis factor
Also known as	DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892
Map Location	6p21.33
Variation Type	SNP
refSNP ID	308A/G

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	allele-specific PCR
Disease	MS
Disease subtype	N/A
Population	Azerbaijani
Sample Size	152 Azeri MS patients / 240 healthy

Literature information of multiple sclerosis :

Pubmed ID	32368988
Year	2021
Title	IFN-γ and TNF-α Gene Polymorphisms in Multiple Sclerosis Patients in Northwest Iran

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	For the TNF-α 308 G/A SNP, the highest allelic and genotypic frequencies in MS patients were the G allele and AG genotype.The genotypes of AA and AG at the TNF-α gene (-308) at the position-308 were considered as potential risk factors for MS.
Mechanism/Pathway	Cytokines are polypeptides that play critical roles in immune responses. Gene polymorphisms occurring in the inflammatory cytokines are taking a role in autoimmune diseases, including multiple sclerosis (MS), which may induce inappropriate immune responses.