Basic information of HLA-DQB1 :
| Official Symbol of Gene | HLA-DQB1 |
| Species | Homo sapiens (human) |
| Entrez Gene ID | 3119 |
| Official Full Name | major histocompatibility complex, class II, DQ beta 1 |
| Also known as | IDDM1; CELIAC1; HLA-DQB |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179344 MIM:604305; AllianceGenome:HGNC:4944 |
| Map Location | 6p21.32 |
| Variation Type | haplotype |
| refSNP ID | *0602 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR/SSO |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Spanish |
| Sample Size | 149 patients / 160 without MS |
Literature information of multiple sclerosis :
| Pubmed ID | 15083289 |
| Year | 2004 |
| Title | DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | DQB1*0602 was the only allele that maintained an association with MS in a logistic regression model. |
| Mechanism/Pathway | The genomic region that codes for the major histocompatibility complex (MHC) has been most consistently associated with MS. The human leukocyte antigens (HLA) class II DR2 haplotype has been associated in varying degrees with MS in all ethnic groups, but particularly strongly in Caucasians. |
