Basic information of NR3C1 :
| Official Symbol of Gene | NR3C1 |
| Species | Homo sapiens |
| Entrez Gene ID | 2908 |
| Official Full Name | nuclear receptor subfamily 3 group C member 1 |
| Also known as | GR; GCR; GRL; GCCR; GCRST |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000113580 MIM:138040; AllianceGenome:HGNC:7978 |
| Map Location | 5q31.3 |
| Variation Type | SNP |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | CIS-MS,RRMS,PPMS,SPMS |
| Population | Chinese |
| Sample Size | 97 patients |
Literature information of multiple sclerosis :
| Pubmed ID | 32277392 |
| Year | 2020 |
| Title | Glucocorticoid receptor mutations and clinical sensitivity to glucocorticoid in Chinese multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Treatment risk |
| Main Result | Negative |
| Result | No significant difference in the mutation distribution was detected between the responders and non-responders to GC therapy. |
| Mechanism/Pathway | GC is the first-line therapy in acute attack of MS, and GR plays a critical role in the therapeutic effects of GC. Several GR gene polymorphisms have been reported to be associated with either glucocorticoid hypersensitivity or glucocorticoid resistance in various diseases. |
