Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | allele |
| refSNP ID | –308 in the TNFα promotor |
Sample information of multiple sclerosis:
| Detected Sample | EDTA blood |
| Sample Detail | N/A |
| Detected Method | allelic discrimination PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Germany |
| Sample Size | 283 MS patients / 72 patients with amyotrophic lateral sclerosis (ALS) and 66 stroke patients |
Literature information of multiple sclerosis :
| Pubmed ID | 10552245 |
| Year | 1999 |
| Title | Gene polymorphism at position -308 of the tumor necrosis factor alpha promotor is not associated with disease progression in multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | We found no statistically significant differences between the TNF2 allelic frequencies in the groups of patients with MS, ALS, and stroke. |
| Mechanism/Pathway | Tumor-necrosis factor-α (TNFα) is a major proinflammatory cytokine secreted mainly by macrophages and the TH1 subset of T-helper cells. Increased expression of TNFα has been shown to be associated with clinical activity in relapsing remitting MS and the development of chronic progressive disease. TNFα augments the immune response by induction of MHC class II antigens, adhesion molecule expression, and blood-brain barrier dysfunction. Finally, TNFα has been shown directly to cause oligodendrocyte damage and demyelination in vitro. |
