Basic information of IFNLR1 :
| Official Symbol of Gene | IFNLR1 |
| Species | Homo sapiens |
| Entrez Gene ID | 163702 |
| Official Full Name | interferon lambda receptor 1 |
| Also known as | IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000185436 MIM:607404; AllianceGenome:HGNC:18584 |
| Map Location | 1p36.11 |
| Variation Type | SNP |
| refSNP ID | rs4649203 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | Illumina Bead Array Matrix SNP panel |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Basque-Spanish |
| Sample Size | 2582 cases / 2614 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 22386267 |
| Year | 2012 |
| Title | Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | We did not detect any consistent association of this locus with MS after an exhaustive investigation of polymorphisms. |
| Mechanism/Pathway | IL28RA codes for a transmembrane protein that heterodimerizes with another subunit, IL-10RB, to form a type II cytokine receptor, which binds IL-28A, IL-28B and IL-29. These ligands, which are distantly related to class I interferons, are activated upon viral infection and trigger the JAK-STAT signaling pathway to exert antiviral activity. The class III interferon pathway is likely to influence susceptibility to various inflammatory and infectious diseases, and polymorphisms in genes integrating this pathway have been related to several conditions. |
