Basic information of MIF :

Official Symbol of Gene	MIF
Species	Homo sapiens
Entrez Gene ID	4282
Official Full Name	macrophage migration inhibitory factor
Also known as	GIF; GLIF; MMIF
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000240972 MIM:153620; AllianceGenome:HGNC:7097
Map Location	22q11.23
Variation Type	SNP
refSNP ID	173 G/C

Sample information of multiple sclerosis:

Detected Sample	blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	RRMS,PPMS,SPMS
Population	Caucasian
Sample Size	44 control / 31 RRMS DS < 10 year / 111 RRMS DS > 10 year / 78 RRMS DS > 15 year / 270 SPMS + PPMS

Literature information of multiple sclerosis :

Pubmed ID	28923927
Year	2017
Title	MIF and D-DT are potential disease severity modifiers in male MS subjects

Results of multiple sclerosis :

Risk Type	Phenotypic risk
Main Result	Positive
Result	The frequency of the 173 C-containing allele, was significantly underrepresented in RRMS subjects with disease duration of more than 10 or 15 year compared with progressive MS subjects.
Mechanism/Pathway	MIF was one of the first cytokines to be described and is a key mediator of many autoimmune inflammatory diseases.It was suggested that MIF contributes to the pathogenesis of EAE/MS by promoting leukocyte recruitment into the CNS, inhibiting apoptosis of activated monocytes, and enhancing the secretion of proinflammatory cytokines.