Basic information of DDT :

Official Symbol of Gene	DDT
Species	Homo sapiens
Entrez Gene ID	1652
Official Full Name	D-dopachrome tautomerase
Also known as	D-DT; DDCT; MIF2; MIF-2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000099977 MIM:602750; AllianceGenome:HGNC:2732
Map Location	22q11.23
Variation Type	polymorphism
refSNP ID	rs5844572(794 CATT5–8)

Sample information of multiple sclerosis:

Detected Sample	blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	RRMS,PPMS,SPMS
Population	Caucasian
Sample Size	44 control / 31 RRMS DS < 10 year / 111 RRMS DS > 10 year / 78 RRMS DS > 15 year / 270 SPMS + PPMS

Literature information of multiple sclerosis :

Pubmed ID	28923927
Year	2017
Title	MIF and D-DT are potential disease severity modifiers in male MS subjects

Results of multiple sclerosis :

Risk Type	Phenotypic risk
Main Result	Positive
Result	The frequency of the 794 CATT7 or the high-expression 794 CATT8-containing genotype alone also was lower in RRMS subjects with long disease duration compared with progressive MS subjects.
Mechanism/Pathway	D-DT has a neuroinflammatory role and similarly affects cell migration.