Basic information of CNTF :
| Official Symbol of Gene | CNTF |
| Species | Homo sapiens |
| Entrez Gene ID | 1270 |
| Official Full Name | ciliary neurotrophic factor |
| Also known as | HCNTF |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000242689 MIM:118945; AllianceGenome:HGNC:2169 |
| Map Location | 11q12.1 |
| Variation Type | mutation |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | N/A |
| Sample Size | 349 MS / 434 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 11857064 |
| Year | 2002 |
| Title | A null mutation within the ciliary neurotrophic factor (CNTF)-gene: implications for susceptibility and disease severity in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Negative |
| Result | The frequency of patients with early or late onset of the disease and clinical course of RRMS, SPMS or PPMS was not different in patients homozygous for the CNTF 01 allele or those heterozygous for the CNTF alleles 01 and 02.The CNTF-genotype was not correlated with disease progression, ie, similar frequencies were obtained for patients classified as having less severe, moderately severe or severe MS. |
| Mechanism/Pathway | While CNTF was initially characterized as a trophic factor for neurons5–7 more recent evidence supports the role for survival, proliferation, and maturation of oligodendrocyte lineage cells.In addition CNTF protects oligodendrocytes from TNF-α induced cell death and was found to be increased in cerebrospinal fluid (CSF) of MS patients recovering from acute exacerbations. |
