Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | polymorphism |
| refSNP ID | TNFα–308 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | allele-specific PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Serbian |
| Sample Size | 143 MS patients / 123 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 12824709 |
| Year | 2003 |
| Title | Decreased frequency of the tumor necrosis factor alpha -308 allele in Serbian patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Negative |
| Result | As for the course of the disease, patients were divided into 2 groups: bout onset disease (RR and secondary progressive) and primary progressive disease.No differences were found in TNF2 allelic frequencies between the subgroups of MS patients subdivided according to the course and the familial occurrence of the disease. |
| Mechanism/Pathway | TNF has been considered as the prototypic cytopathogenic cytokine in MS, due to its effects on the induction of adhesion molecules on endothelial cells and enhancement of circulating cell entry in the central nervous system (CNS) , as well as on induction of oligodendrocyte injury and demyelination. |
