Basic information of CXCL12 :
| Official Symbol of Gene | CXCL12 |
| Species | Homo sapiens |
| Entrez Gene ID | 6387 |
| Official Full Name | C-X-C motif chemokine ligand 12 |
| Also known as | IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000107562 MIM:600835; AllianceGenome:HGNC:10672 |
| Map Location | 10q11.21 |
| Variation Type | polymorphism |
| refSNP ID | SDF-13'a |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RLFP |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 100 MS patients / 100 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 22125123 |
| Year | 2011 |
| Title | The SDF-1 3'a genetic variation of the chemokine SDF-1α (CXCL12) in parallel with its increased circulating levels is associated with susceptibility to MS: a study on Iranian multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Our results showed a significant difference between the A/A, A/G, and G/G genotype and A and G alleles of polymorphisms at position +801 of SDF-1α (CXCL12). |
| Mechanism/Pathway | Immune regulatory factors might influence the pathogenesis of MS. Chemokines are low molecular weight proteins. A chemokine network exists in the CNS which is involved in physiological responses, under certain circumstances, pathological and repair processes subsequent to neurological injury.Based on the significant role that CXCL12 axis plays in hematopoiesis including hematopoietic cell differentiation and survival and homing of hematopoietic progenitors to the bone marrow and regulation of neuronal progenitor cell migration in the CNS, thus, genetic factors that lead to elevated expression of this chemokine enable the immune system to induce a vigorous immune response against CNS antigens in MS patients. |
