Basic information of CLEC16A :
| Official Symbol of Gene | CLEC16A |
| Species | Homo sapiens |
| Entrez Gene ID | 23274 |
| Official Full Name | C-type lectin domain containing 16A |
| Also known as | Gop-1; KIAA0350 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000038532 MIM:611303; AllianceGenome:HGNC:29013 |
| Map Location | 16p13.13 |
| Variation Type | SNP |
| refSNP ID | rs12708716 , rs12923849 |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | N/A |
| Detected Method | real-time PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | British |
| Sample Size | 1113 British trios / 1097 UK cases / 1966 UK controls |
Literature information of multiple sclerosis :
| Pubmed ID | 21179112 |
| Year | 2010 |
| Title | Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | In the UK replication sample set, rs12708716 and rs12923849 were significantly associated in the trios and case controls combined. |
| Mechanism/Pathway | The association of CLEC16A SNPs across multiple immune-mediated diseases and the observation that the gene is almost uniquely expressed on immune cells, make a common effect on autoimmunity likely.The CLEC16A protein belongs to the C-type lectin family whose immune functions include differentiation of self versus non-self glycoproteins and the induction of the appropriate immune response. |
