Basic information of IL7R :

Official Symbol of Gene	IL7R
Species	Homo sapiens
Entrez Gene ID	3575
Official Full Name	interleukin 7 receptor
Also known as	ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024
Map Location	5p13.2
Variation Type	SNP
refSNP ID	rs6897932

Sample information of multiple sclerosis:

Detected Sample	N/A
Sample Detail	N/A
Detected Method	real-time PCR
Disease	MS
Disease subtype	PPMS,conventional MS (CMS),opticospinal MS (OSMS)
Population	Asian
Sample Size	265 patients / 158 unrelated healthy controls

Literature information of multiple sclerosis :

Pubmed ID	21670443
Year	2011
Title	Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	The frequencies of both the C allele and the CC genotype of SNP rs6897932 in the IL-7RA gene in patients with non-NMO MS were significantly higher than those of HCs.However, there was no significant difference in the frequency of either the C allele or the CC genotype between HCs and patients with NMO. The frequencies of both the C allele and the CC genotype were significantly higher in patients with CMS than in HCs, but not in patients with OSMS. This study revealed a significant association of the SNP rs6897932 of IL-7RA gene with non-NMO MS in Japanese populations.
Mechanism/Pathway	The SNP located in the transmembrane domain of IL-7Rα is nonsynonymous and functional: the MS-susceptible CC allele increases levels of the soluble form of IL-7Rα via exon skipping, and decreases the expression of membranebound IL-7Rα, thereby causing decreased IL-7/ IL-7R signaling.IL-7/IL-7R signaling induces thymic production of FOXP3 regulatory T cells, which efficiently ameliorate experimental autoimmune encephalomyelitis,an animal model of MS.