Basic information of LEP :

Official Symbol of Gene	LEP
Species	Homo sapiens
Entrez Gene ID	3952
Official Full Name	leptin
Also known as	OB; OBS; LEPD
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000174697 MIM:164160; AllianceGenome:HGNC:6553
Map Location	7q32.1
Variation Type	SNP
refSNP ID	rs11761556,rs2167270,rs7799039

Sample information of multiple sclerosis:

Detected Sample	N/A
Sample Detail	N/A
Detected Method	real-time PCR
Disease	MS
Disease subtype	RRMS,PPMS,SPMS,CIS
Population	German
Sample Size	776 MS patients / 878 control subjects

Literature information of multiple sclerosis :

Pubmed ID	21664965
Year	2011
Title	Polymorphisms in genes encoding leptin, ghrelin and their receptors in German multiple sclerosis patients

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Negative
Result	Allele and genotype frequencies did not differ significantly between MS patients and controls.
Mechanism/Pathway	Leptin also plays an important role in the regulation of immune responses and pro-inflammatory cytokine secretion.It binds to the leptin receptor (LEPR), which belongs to the class I cytokine receptor superfamily and acts through the classical JAK-STAT pathway.