Basic information of LEPR :

Official Symbol of Gene	LEPR
Species	Homo sapiens
Entrez Gene ID	3953
Official Full Name	leptin receptor
Also known as	OBR; OB-R; CD295; LEP-R; LEPRD
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000116678 MIM:601007; AllianceGenome:HGNC:6554
Map Location	1p31.3
Variation Type	SNP
refSNP ID	rs1137100,rs1137101,rs8179183

Sample information of multiple sclerosis:

Detected Sample	N/A
Sample Detail	N/A
Detected Method	real-time PCR
Disease	MS
Disease subtype	RRMS,PPMS,SPMS,CIS
Population	German
Sample Size	776 MS patients / 878 control subjects

Literature information of multiple sclerosis :

Pubmed ID	21664965
Year	2011
Title	Polymorphisms in genes encoding leptin, ghrelin and their receptors in German multiple sclerosis patients

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Negative
Result	Allele and genotype frequencies did not differ significantly between MS patients and controls.
Mechanism/Pathway	Leptin also plays an important role in the regulation of immune responses and pro-inflammatory cytokine secretion.It binds to the leptin receptor (LEPR), which belongs to the class I cytokine receptor superfamily and acts through the classical JAK-STAT pathway.