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Basic information of SPP1 :

Official Symbol of Gene SPP1
Species Homo sapiens
Entrez Gene ID 6696
Official Full Name secreted phosphoprotein 1
Also known as OPN; BNSP; BSPI; ETA-1
Gene Type protein coding
dbXrefs Ensembl:ENSG00000118785 MIM:166490; AllianceGenome:HGNC:11255
Map Location 4q22.1
Variation Type SNP
refSNP ID rs1126616

Sample information of multiple sclerosis:

Detected Sample N/A
Sample Detail N/A
Detected Method N/A
Disease MS
Disease subtype RRMS,PPMS,SPMS
Population Spanish
Sample Size 326 MS patients / 484 healthy controls

Literature information of multiple sclerosis :

Pubmed ID 17439891
Year 2007
Title The 795CT polymorphism in osteopontin gene is not associated with multiple sclerosis in a Spanish population

Results of multiple sclerosis :

Risk Type Disease risk
Main Result Negative
Result When global and one-by-one comparisons between both groups were made, no significant differences were observed.No differences were apparent when allelic or phenotypic (carrier) frequencies were compared instead.
Mechanism/Pathway Osteopontin (OPN) is a Th1 cytokine with multiple functions in inflammation and immunity, and in bone metabolism.