Basic information of IRF1 :

Official Symbol of Gene	IRF1
Species	Homo sapiens
Entrez Gene ID	3659
Official Full Name	interferon regulatory factor 1
Also known as	MAR; IRF-1
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000125347 MIM:147575; AllianceGenome:HGNC:6116
Map Location	5q31.1
Variation Type	allele
refSNP ID	GT repeat alleles

Sample information of multiple sclerosis:

Detected Sample	N/A
Sample Detail	N/A
Detected Method	automated fluorescence sequencing system
Disease	MS
Disease subtype	RRMS,PPMS,SPMS
Population	European populations (Germany, Sweden and Northern Italy)
Sample Size	574 MS patients / 527 healthy control

Literature information of multiple sclerosis :

Pubmed ID	11196707
Year	2000
Title	Lack of association between the interferon regulatory factor-1 (IRF1) locus at 5q31.1 and multiple sclerosis in Germany, northern Italy, Sardinia and Sweden

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Negative
Result	In none of these populations, did we find any significant allelic association with disease.
Mechanism/Pathway	Because of their complex effects on the induction and maintenance of inflammatory reactions, cytokines and interferons are considered as an important class of disease-promoting or limiting effector molecules. While administration of IFN-g leads to exacerbation of the disease, recombinant IFN-b reduces exacerbation rates and destruction of the central nervous system (CNS) components. Interferon regulatory factor-1 (IRF-1) is a transcriptional activator of the IFN-b gene, and is itself induced by cytokines such as IFN-g and IL-12.