Basic information of NRG1 :
| Official Symbol of Gene | NRG1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3084 |
| Official Full Name | neuregulin 1 |
| Also known as | GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000157168 MIM:142445; AllianceGenome:HGNC:7997 |
| Map Location | 8p12 |
| Variation Type | SNP |
| refSNP ID | rs6994992 |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | N/A |
| Detected Method | PCR-RLFP |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Iranian |
| Sample Size | 165 MS / 200 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 25802071 |
| Year | 2015 |
| Title | Two functional promoter polymorphisms of neuregulin 1 gene are associated with progressive forms of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | No significant difference in the allelic and genotype frequencies of the NRG1 polymorphism between MS patients and control group in Iranian population. |
| Mechanism/Pathway | Neuregulin 1 (NRG1) is a signaling protein that mediates cell–cell interactions and plays critical roles in the growth of the nervous system. This gene has isoforms which are generated through alternative splicing and different promoter usage. |
