Basic information of NRG1 :
| Official Symbol of Gene | NRG1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3084 |
| Official Full Name | neuregulin 1 |
| Also known as | GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000157168 MIM:142445; AllianceGenome:HGNC:7997 |
| Map Location | 8p12 |
| Variation Type | SNP |
| refSNP ID | rs6994992 |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | N/A |
| Detected Method | PCR-RLFP |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Iranian |
| Sample Size | 165 MS / 200 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 25802071 |
| Year | 2015 |
| Title | Two functional promoter polymorphisms of neuregulin 1 gene are associated with progressive forms of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | By classification for clinical MS groups, significant difference in the genotype frequency was observed between SPMS patients and controls for SNP rs6994992 and also, a significant difference in the allelic distributions between PPMS patients and controls was revealed;there was a significant shift in frequency of C allele between PPMS group vs. other type of MS. |
| Mechanism/Pathway | Neuregulin 1 (NRG1) is a signaling protein that mediates cell–cell interactions and plays critical roles in the growth of the nervous system. This gene has isoforms which are generated through alternative splicing and different promoter usage. |
