Basic information of NRG1 :
| Official Symbol of Gene | NRG1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3084 |
| Official Full Name | neuregulin 1 |
| Also known as | GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000157168 MIM:142445; AllianceGenome:HGNC:7997 |
| Map Location | 8p12 |
| Variation Type | SNP |
| refSNP ID | rs7014762 |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | N/A |
| Detected Method | mismatch PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Iranian |
| Sample Size | 165 MS / 200 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 25802071 |
| Year | 2015 |
| Title | Two functional promoter polymorphisms of neuregulin 1 gene are associated with progressive forms of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | Considering rs7014762 polymorphism frequencies, significant difference was observed between primary progressive MS group in comparison to the control group. |
| Mechanism/Pathway | Neuregulin 1 (NRG1) is a signaling protein that mediates cell–cell interactions and plays critical roles in the growth of the nervous system. This gene has isoforms which are generated through alternative splicing and different promoter usage. |
