Basic information of HNMT :
| Official Symbol of Gene | HNMT |
| Species | Homo sapiens |
| Entrez Gene ID | 3176 |
| Official Full Name | histamine N-methyltransferase |
| Also known as | HMT; MRT51; HNMT-S1; HNMT-S2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000150540 MIM:605238; AllianceGenome:HGNC:5028 |
| Map Location | 2q22.1 |
| Variation Type | polymorphism |
| refSNP ID | Thr/Ile |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | N/A |
| Detected Method | PCR-RLFP |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Caucasian |
| Sample Size | 228 MS patients / 295 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 19538200 |
| Year | 2009 |
| Title | Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | The frequencies of HNMT genotypes and HNMTIle alleles in patients with MS did not differ significantly from those of controls. |
| Mechanism/Pathway | Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis-MS) in the CNS. |
