Basic information of MMP9 :

Official Symbol of Gene	MMP9
Species	Homo sapiens
Entrez Gene ID	4318
Official Full Name	matrix metallopeptidase 9
Also known as	GELB; CLG4B; MMP-9; MANDP2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000100985 MIM:120361; AllianceGenome:HGNC:7176
Map Location	20q13.12
Variation Type	polymorphism
refSNP ID	N/A

Sample information of multiple sclerosis:

Detected Sample	N/A
Sample Detail	N/A
Detected Method	microsatellite fragment analysis
Disease	MS
Disease subtype	N/A
Population	Swedish
Sample Size	195 MS patients / 145 control subjects

Literature information of multiple sclerosis :

Pubmed ID	10713364
Year	2000
Title	Polymorphism analysis suggests that the gelatinase B gene is not a susceptibility factor for multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Negative
Result	No significant differences in overall allelic or genotype frequencies were observed between the diseased and control subpopulation.
Mechanism/Pathway	Based on mononuclear cell infiltrations in multiple sclerosis (MS) lesions, MS is classified as an auto immune demyelinating disease of unknown etiology. The evidences for a pathophysiological role of gelatinase B in MS are multiple but circumstantial: production by mononuclear cells, detection in the cerebrospinal fluid of MS patients, but not in neurological controls, and correlation with the IgG index in MS patients, occurrence of protein and mRNA in demyelinating areas in CNS tissues of MS patients, association of immunoreactivity with lesion evolution, and parallelism of the protease load, i.e. a tendency for increased gelatinase B and decreased TIMP serum levels, with MRI analysis.