Basic information of APOE :
| Official Symbol of Gene | APOE |
| Species | Homo sapiens |
| Entrez Gene ID | 348 |
| Official Full Name | apolipoprotein E |
| Also known as | AD2; LPG; APO-E; ApoE4; LDLCQ5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613 |
| Map Location | 19q13.32 |
| Variation Type | allele |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Italian |
| Sample Size | 871 patients / 348 control subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 15699400 |
| Year | 2005 |
| Title | HLA-DR,DQ and APOE genotypes and gender influence in Sardinian primary progressive MS |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Distribution of APOE genotypes did not differ in patients and control subjects.No variation in risk was found in patients carrying allele 3 in a homozygous state or in those having the 2/3 or 2/2 genotype. |
| Mechanism/Pathway | The APOE gene, located in the 19q13 region, codes for a major lipid carrier protein (apoE) in the brain. This protein, associated with myelin and axon repair following lesion of the central and peripheral nervous system, modulates brain inflammation with an isoform-specific effect. |
