Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | allele |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | leucocytes |
| Sample Detail | N/A |
| Detected Method | reverse dot-blot method |
| Disease | MS |
| Disease subtype | N/A |
| Population | Caucasian |
| Sample Size | 375 white patients with clinically definite MS / 367 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 11374095 |
| Year | 2001 |
| Title | HLA-DRB1 and disease outcome in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | A significant difference between patients and expected values was noted.The HLA-DRB1*15 allele was found more commonly in MS patients than in controls.A second HLA-DRB1 allele, HLA-DRB1*03, was found significantly more frequently in the patient group after this manoeuvre.The presence of HLA-DRB1*15 was estimated to give an approximately five-fold risk of MS.The risk in HLA-DRB1*15 homozygotes was not statistically different to the risk in HLA-DRB1*15 heterozygotes. |
| Mechanism/Pathway | N/A |
