Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | methylation-mediated SNP |
| refSNP ID | rs9267649 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | N/A |
| Detected Method | MSRE-qPCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Scandinavian |
| Sample Size | 8172 cases / 13263 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 29921915 |
| Year | 2018 |
| Title | DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | rs9267649 displayed a genome-wide significant association with MS with a similar protective effect in all cohorts . |
| Mechanism/Pathway | Genetic variants in the loci encoding epigenetic machinery genes have been associated with MS suggesting a role for epigenetic mechanisms in disease pathology. |
