Basic information of CCL20 :
| Official Symbol of Gene | CCL20 |
| Species | Homo sapiens |
| Entrez Gene ID | 6364 |
| Official Full Name | C-C motif chemokine ligand 20 |
| Also known as | CKb4; LARC; ST38; MIP3A; Exodus; MIP-3a; SCYA20; MIP-3-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000115009 MIM:601960; AllianceGenome:HGNC:10619 |
| Map Location | 2q36.3 |
| Variation Type | SNP |
| refSNP ID | rs6749704 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | real-Time PCR |
| Disease | MS |
| Disease subtype | RRMS,SPMS |
| Population | Egyptian |
| Sample Size | 83 patients / 95 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 30399422 |
| Year | 2019 |
| Title | The combined effect of IL-17F and CCL20 gene polymorphism in susceptibility to multiple sclerosis in Egypt |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Frequencies of CT genotype of rs6749704 in CCL20 gene and C allele in MS patients were significantly higher compared to controls. |
| Mechanism/Pathway | The migration of auto reactive T cells from circulation into the CNS across the (BBB) is a crucial step in the development of pathological lesions in MS, the recruitment of inflammatory cells is controlled by chemokines.CCL20–CCR6 interaction participates in BBB disruption and the subsequent transmigration of pathogenic T cell into the CNS.Moreover, secretion of IL-17 from circulating Th17 cells amplifies the proinflammatory response by enhancing CCL20 transcription via NFkB signaling. |
