Basic information of IL17F :
| Official Symbol of Gene | IL17F |
| Species | Homo sapiens |
| Entrez Gene ID | 112744 |
| Official Full Name | interleukin 17F |
| Also known as | ML1; ML-1; IL17A; CANDF6; IL-17F |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000112116 MIM:606496; AllianceGenome:HGNC:16404 |
| Map Location | 6p12.2 |
| Variation Type | SNP |
| refSNP ID | rs763780 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | real-Time PCR |
| Disease | MS |
| Disease subtype | RRMS,SPMS |
| Population | Egyptian |
| Sample Size | 83 patients / 95 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 30399422 |
| Year | 2019 |
| Title | The combined effect of IL-17F and CCL20 gene polymorphism in susceptibility to multiple sclerosis in Egypt |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Significant increase of rs763780 in IL-17F gene was detected in MS patients. |
| Mechanism/Pathway | IL-17 is correlated with disease activity and promote blood-brain barrier (BBB) disruption and CNS inflammation.The IL-17F 7488T/C polymorphism (rs763780) causes an amino acid substitution from histamine to arginine at codon 161 (H161R), in the third exon of the IL17F gene. |
