Basic information of RT1-Db1 :
| Official Symbol of Gene | RT1-Db1 |
| Species | Rattus norvegicus (Norway rat) |
| Entrez Gene ID | 294270 |
| Official Full Name | RT1 class II, locus Db1 |
| Also known as | Db1; RT1-Db; RT1-Db1n |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSRNOG00000033215 AllianceGenome:RGD:1593282 |
| Map Location | 20p12 |
| Variation Type | haplotype |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | spinal cord |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | EAE |
| Disease subtype | relapsing EAE (SPR-EAE) |
| Population | rats |
| Sample Size | DA rats with RT1av1-homozygous individuals from the DA-backcross and F2-intercross,(DE×BN)F1 rats |
Literature information of multiple sclerosis :
| Pubmed ID | 9413257 |
| Year | 1997 |
| Title | Genetic analysis of inflammation, cytokine mRNA expression and disease course of relapsing experimental autoimmune encephalomyelitis in DA rats |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Susceptibility to EAE is inherited in a dominant fashion while susceptibility to SPR-EAE is not .The RT1av1 haplotype was associated with high susceptibility to EAE, development of severe/lethal ,relapses and a prolonged disease course. |
| Mechanism/Pathway | N/A |
