Basic information of Tagap :
| Official Symbol of Gene | Tagap |
| Species | Mus musculus |
| Entrez Gene ID | 72536 |
| Official Full Name | T cell activation Rho GTPase activating protein |
| Also known as | TRD; Tcd1; tcs1; Tcd-1; Tcd1a; tcs-1; 2610315E15Rik |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000033450 AllianceGenome:MGI:3615484 |
| Map Location | 17; 17 A1 |
| Variation Type | Deletion |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | bone marrow-derived macrophages (BMDMs) |
| Sample Detail | heterozygous control mice or TAGAP-deficient mice |
| Detected Method | immunoblot analysis,co-immunoprecipitation |
| Disease | heat-killed C. albicans, Curdlan, and α-Mannan infection |
| Disease subtype | N/A |
| Population | mice (MGI ID 3603008) |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 32312989 |
| Year | 2020 |
| Title | TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | TAGAP can bind Dectin-1, whereas TAGAPΔGAP cannot. TAGAP also bound to Dectin-2, whereas TAGAPΔGAP did not.Wild-type TAGAP interacted with EPHB2 whereas TAGAPΔGAP mutant showed greatly reduced binding to EPHB2. |
| Mechanism/Pathway | The GAP domain of TAGAP is essential for the recruitment of TAGAP to Dectin-1 and mediating the binding to EPHB2. |
