Basic information of TAGAP :
| Official Symbol of Gene | TAGAP |
| Species | Homo sapiens |
| Entrez Gene ID | 117289 |
| Official Full Name | T cell activation RhoGTPase activating protein |
| Also known as | FKSG15; IDDM21; TAGAP1; ARHGAP47 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000164691 MIM:609667; AllianceGenome:HGNC:15669 |
| Map Location | 6q25.3 |
| Variation Type | SNP |
| refSNP ID | rs1738074,rs3127214 |
Sample information of multiple sclerosis:
| Detected Sample | PBMCs |
| Sample Detail | N/A |
| Detected Method | RT and real-time PCR |
| Disease | Curdlan and α-mannan stimulated |
| Disease subtype | N/A |
| Population | human |
| Sample Size | n = 17, 10, 11 for rs1738074; n = 12, 13, 15 rs3127214 |
Literature information of multiple sclerosis :
| Pubmed ID | 32312989 |
| Year | 2020 |
| Title | TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We found that PBMCs from individuals carries the TAGAP rs1738074 C/C genotype had the significant higher TAGAP mRNA expression levels compared with that from rs1738074 T/C and T/T carriers, whereas PBMCs of rs3127214 T/T carriers had significantly lower TAGAP mRNA levels compared with that of rs3127214 C/T and C/C carriers .Furthermore, Th17 cell abundance was positively correlated with the TAGAP mRNA levels in PBMCs from both of two genotypes.The lower Th17 abundance in the PBMCs of rs3127214 polymorphism carrier could very well explain its susceptibility to candidemia, as Th17 cells were known to play the most critical role in host defense against fungi, such as C. albicans. PBMC-induced proinflammatory gene expression in response to different stimuli was positively correlated with TAGAP mRNA level . |
| Mechanism/Pathway | Th17 cells were known to play the most critical role in host defense against fungi, such as C. albicans. |
