Basic information of Tagap :

Official Symbol of Gene	Tagap
Species	Mus musculus
Entrez Gene ID	72536
Official Full Name	T cell activation Rho GTPase activating protein
Also known as	TRD; Tcd1; tcs1; Tcd-1; Tcd1a; tcs-1; 2610315E15Rik
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000033450 AllianceGenome:MGI:3615484
Map Location	17; 17 A1
Variation Type	Deletion
refSNP ID	N/A

Sample information of multiple sclerosis:

Detected Sample	spinal cords,brains
Sample Detail	heterozygous control mice and TAGAP-deficient mice in EAE;rag2-deficient mice transferred with wild-type or TAGAP-deficient CD4+ T cells
Detected Method	RT and real-time PCR,flow cytometry analysis, immunoblot analysis,H&E staining and LFB staining
Disease	EAE
Disease subtype	inducted by MOG3555 and Mycobacteria tuberculosis H37RA (Difco)
Population	mice (MGI ID 3603008)
Sample Size	5

Literature information of multiple sclerosis :

Pubmed ID	32312989
Year	2020
Title	TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response

Results of multiple sclerosis :

Risk Type	Phenotypic risk
Main Result	Positive
Result	TAGAP-deficient mice showed a delay in the onset of neurological impairment and much lower disease severity.Perivascular leukocyte infiltration and demyelination were much more prominent in the spinal cords of heterozygous control mice compared with TAGAP-deficient mice.There was a marked decrease in the expression levels of ‘signature’ IL-17-responsive genes, such as CXCL1, CXCL2, IL-6, and IL-1β, in the spinal cords of TAGAP-deficient mice compared with heterozygous control mice. There was a great degree of mononuclear cell infiltration in the brain white matter and spinal cords of heterozygous control mice than in TAGAP-deficient mice .The Th17 and Th1 cells in the peripheral blood and brain were also comparable between Rag2-deficient mice transferred with wild-type or TAGAP-deficient CD4+ T cells.
Mechanism/Pathway	N/A