Basic information of IL2RA :
| Official Symbol of Gene | IL2RA |
| Species | Homo sapiens |
| Entrez Gene ID | 3559 |
| Official Full Name | interleukin 2 receptor subunit alpha |
| Also known as | interleukin 2 receptor subunit alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000134460 MIM:147730; AllianceGenome:HGNC:6008 |
| Map Location | 10p15.1 |
| Variation Type | SNP |
| refSNP ID | rs12722489,rs2104286 |
Sample information of multiple sclerosis:
| Detected Sample | genotype,susceptibility to and severity of multiple sclerosis (MS) |
| Sample Detail | N/A |
| Detected Method | population-based cohort, restriction fragment length polymorphism (RFLP) following polymerase chain reaction (PCR) amplification |
| Disease | MS |
| Disease subtype | N/A |
| Population | Olmsted County, Minnesota |
| Sample Size | 220 patients ,442 matched controls |
Literature information of multiple sclerosis :
| Pubmed ID | 21239413 |
| Year | 2011 |
| Title | Association of IL2RA polymorphisms with susceptibility to multiple sclerosis is not explained by missense mutations in IL2RA |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | rs12722489 and rs2104286 were not in linkage disequilibrium with each other in cases or controls. We did not find association between haplotypes, genotypes or alleles of rs12722489 and rs21042861 and susceptibility to MS in our populationbased sample. There was no association with disease severity and no gender-dependent effect. |
| Mechanism/Pathway | N/A |
