Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | SNP |
| refSNP ID | —308 polymorphism |
Sample information of multiple sclerosis:
| Detected Sample | leukocytes |
| Sample Detail | N/A |
| Detected Method | Polymerase chain reaction (PCR) amplification,Polymerase chain reaction (PCR) amplification. Allele-specific PCR. |
| Disease | MS |
| Disease subtype | N/A |
| Population | Olmsted County |
| Sample Size | 117(78 MS patients and in 39 patients with schizophrenia) |
Literature information of multiple sclerosis :
| Pubmed ID | 9270565 |
| Year | 1997 |
| Title | Genetic variation in the tumor necrosis factor alpha gene and the outcome of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Negative |
| Result | We studied the association of the two most common mutations with the mean ranked severity score and with the temporal profile of MS in patients with available clinical information.No association was evident.An analysis of the distribution of severity scores and a linear regression analysis of EDSS according to duration did not reveal any differences between those with the variants and the wild-type sequence. |
| Mechanism/Pathway | N/A |
