Basic information of HLA-DRB1 :

Official Symbol of Gene	HLA-DRB1
Species	Homo sapiens
Entrez Gene ID	3123
Official Full Name	major histocompatibility complex, class II, DR beta 1
Also known as	SS1; DRB1; HLA-DRB; HLA-DR1B
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948
Map Location	6p21.32
Variation Type	haplotype
refSNP ID	N/A

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	a commercial kit (LABType SSO Typing Tests),alleles’ detection was done using a non-radioactive PCR-SSOP (polymerase chain reaction-based sequence specific oligonucleotide probe) reverse line-blot assay,
Disease	MS
Disease subtype	RRMS
Population	Puerto Ricans
Sample Size	35 patients and 31 controls

Literature information of multiple sclerosis :

Pubmed ID	23767380
Year	2013
Title	HLA class I & II alleles in multiple sclerosis patients from Puerto Rico

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	The odds of having MS in participants with allele HLA-DRB1 *01 was 11.0 (95%CI: 1.1, 109.7) times the odds of having MS in participants classified in the category “others”. This excess was statistically significant (p-value= 0.041).The odds of having MS in participants with allele *03 was 4.3 (95%CI: 0.97, 19.1) times the odds of having MS in participants classified in the category “others”.his excess was marginally significant (p-value=0.054).The odds of having MS in participants with allele *04 was 0.23 (95%CI: 0.05, 1.09) lower than the odds of having MS in participants with allele *02. This excess was marginally significant (p-value=0.066).
Mechanism/Pathway	N/A