Basic information of H2 :

Official Symbol of Gene	H2
Species	Mus musculus
Entrez Gene ID	111364
Official Full Name	histocompatibility-2, MHC
Also known as	N/A
Gene Type	other
dbXrefs	MGI:MGI:95894
Map Location	chromosome: 17
Variation Type	N/A
refSNP ID	N/A

Sample information of multiple sclerosis:

Detected Sample	mononuclear cells
Sample Detail	from blood,spleen ,and BM
Detected Method	injected monitored for clinical GVHD ,flow cytometry staining
Disease	EAE
Disease subtype	N/A
Population	SJL/J and C57BL/6 mice
Sample Size	induce mixed chimerism (n = 25)/controls(treated with PBS (n = 12) or given conditioning only (n = 12))

Literature information of multiple sclerosis :

Pubmed ID	26647186
Year	2015
Title	MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	Induction of mixed chimerism prevents EAE relapse, augments myelin sheath regeneration, prevents axon damage,reverses autoimmunity and eliminates lymphocyte infiltration in spinal tissue,reduces Th17 and increases host-type Treg as well as increases thymic Treg production.Induction of mixed chimerism in thymectomized recipients does not prevent EAE relapse but reduces its severity. Induction of mixed chimerism in late-stage EAE mice eliminates infiltration in spinal tissues but does not cure disease.
Mechanism/Pathway	The mechanisms behind this observation remain unclear and may be explained by the following hypothesis: Although H-2s SJL/J mice are susceptible to induction of EAE by antigen stimulation, the mice never spontaneously develop autoimmune EAE. This phenomenon suggests that under the normal situation, the autoreactive T cells in the peripheral lymphoid tissues of SJL/J mice are tolerized, probably by regulatory T cells such as Foxp3+ Treg cells. After induction of EAE, peripheral autoreactive CD4+ T cells are expanded, infiltrate the CNS, and cause damage of myelin sheaths, axons, and eventually neurons. At the same time, autoreactive T cells migrate into the thymus to damage medullary thymic epithelial cells (mTEC) and impair negative selection. Subsequently, more autoreactive T cells are generated and the disease is perpetuated. Autoreactive T cells can have dual TCRs and have cross-reactivity with mismatched MHC .