Basic information of Eae23 :
| Official Symbol of Gene | Eae23 |
| Species | Rattus norvegicus (Norway rat) |
| Entrez Gene ID | 100303366 |
| Official Full Name | Experimental allergic encephalomyelitis QTL 23 |
| Also known as | N/A |
| Gene Type | unknown |
| dbXrefs | discontinued |
| Map Location | 10; 10 16.93 cM |
| Variation Type | allele |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | lymph nodes |
| Sample Detail | at day 7 p.i. from MOG-immunized |
| Detected Method | RT-PCR |
| Disease | EAE |
| Disease subtype | Rats immunized intradermally in the dorsal tail base with recombinant rat MOG (amino acids 1–125 from the N terminus) expressed in Escherichia Coli. |
| Population | MOG-immunized DA and PVG.1AV1 rats |
| Sample Size | DA(n=6)/ PVG.1AV1 rats(n=6) |
Literature information of multiple sclerosis :
| Pubmed ID | 20856809 |
| Year | 2010 |
| Title | Fine-mapping resolves Eae23 into two QTLs and implicates ZEB1 as a candidate gene regulating experimental neuroinflammation in rat |
Results of multiple sclerosis :
| Risk Type | N/A |
| Main Result | N/A |
| Result | There were no significant differences between the strains in either the shared region of ZEB1 or its downstream target IL2. However, mRNA expression of the splice variant Zfhep2 was higher in DA compared to PVG.1AV1mwhile there was no significant difference in Zfhep1. |
| Mechanism/Pathway | N/A |
