Basic information of CYP24A1 :
| Official Symbol of Gene | CYP24A1 |
| Species | Homo sapiens |
| Entrez Gene ID | 1591 |
| Official Full Name | cytochrome P450 family 24 subfamily A member 1 |
| Also known as | CP24; HCAI; CYP24; HCINF1; P450-CC24 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000019186 MIM:126065; AllianceGenome:HGNC:2602 |
| Map Location | 20q13.2 |
| Variation Type | SNP |
| refSNP ID | rs2762943 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | serum,pbmcs |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 340 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 37183562 |
| Year | 2023 |
| Title | The CYP24A1 gene variant rs2762943 is associated with low serum 1,25-颅dihydroxyvitamin D levels in multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | up-regulation |
| Result | The presence of the rs2762943 risk allele had no significant impact on disease activity and disability outcomes during follow-颅up. However, risk allele carriers were younger at disease onset (p = 0.04). |
| Mechanism/Pathway | is associated with lower 1,25(OH)2D levels and a heightened pro-颅inflammatory environment in MS patients. |
