Basic information of SIRT1 :
| Official Symbol of Gene | SIRT1 |
| Species | Homo sapiens |
| Entrez Gene ID | 23411 |
| Official Full Name | sirtuin 1 |
| Also known as | SIR2; SIR2L1; SIR2alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000096717 MIM:604479; AllianceGenome:HGNC:14929 |
| Map Location | 10q21.3 |
| Variation Type | SNP |
| refSNP ID | rs7895833 |
Sample information of multiple sclerosis:
| Detected Sample | Blood samples |
| Sample Detail | serum |
| Detected Method | TaqMan |
| Disease | MS |
| Disease subtype | N/A |
| Population | Lithuanian |
| Sample Size | 79 patients with ON and 225 healthy subjects were included in the study. ON patients were divided into 2 subgroups: patients with MS (n = 30) and patients without MS (n = 43) |
Literature information of multiple sclerosis :
| Pubmed ID | 36949521 |
| Year | 2023 |
| Title | The role of SIRT1 level and SIRT1 gene polymorphisms in optic neuritis patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | N/A |
| Result | There was no association between SIRT1 levels and ON with/ without MS development. |
| Mechanism/Pathway | N/A |
