Basic information of KCNA3 :
| Official Symbol of Gene | KCNA3 |
| Species | Homo sapiens |
| Entrez Gene ID | 3738 |
| Official Full Name | potassium voltage-gated channel subfamily A member 3 |
| Also known as | MK3; HGK5; HLK3; PCN3; HPCN3; KV1.3; HUKIII |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000177272 MIM:176263; AllianceGenome:HGNC:6221 |
| Map Location | 1p13.3 |
| Variation Type | SNP |
| refSNP ID | rs2821557 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | PBMC |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/SPRS/PPRS+RPRS |
| Population | Iranic |
| Sample Size | 111 patients |
Literature information of multiple sclerosis :
| Pubmed ID | 32056271 |
| Year | 2020 |
| Title | A common genetic variant rs2821557 in KCNA3 is linked to the severity of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | In conclusion, accelerated MS progression in C allele carriers is likely linked to enhanced Kv1.3-mediated accumulation of pathogenic CXCR3+ TEM cells and exacerbated neuroinflammation. |
| Mechanism/Pathway | accumulation of pathogenic CXCR3+ TEM cells and exacerbated neuroinflammation |
